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Chemia & Biochemia

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SKIN-CAD

SKIN-CAD is software for skin-body pharmacokinetic simulation developed based on percutaneous absorption model. SKIN-CAD can predict skin permeation amount and blood concentration by input of various model parameters. It can also analyze the effects of metabolism and binding in the skin, the enhancement by iontophoretic application, and the pharmacokinetic-pharmacodynamic model, etc.

SKIN-CAD can be used for optimizing the design of transdermal drug delivery systems (prediction of clinical performance, setup of administration schedule) as well as for evaluating the effects of various factors on skin permeation and blood concentration profiles. With the model parameters determined from in vitro or in vivo experiments or evaluated from correlation equations, SKIN-CAD can quickly provide you with graphical images; blood concentration - time profile for systemic application, drug distribution in the skin for topical application, skin permeability of skin-care products.
Pobierz testową wersję produktu
Simulation Model
  • Skin permeation model (2-layer or 1-layer).
  • Drug-dissolved matrix system/skin permeation model.
  • Drug-dispersed matrix system/skin permeation model.
  • Vehicle compartment/skin permeation model.

Serum fentanyl concentration-time profiles following transdermal delivery.


 
Input Parameters
  • System application period, applied area.
  • Release characteristics from formulation.
  • Skin structure (thickness of each layer).
  • Diffusion and partition coefficients in skin.
  • Body pharmacokinetic parameters (1-, 2- or 3-compartment model).



Optional Input Parameters:
  • Skin binding parameters (Langmuir type or Freundlich type).
  • Skin metabolism parameters (Michaelis-Menten type or first-order kinetics).
  • Conditions of iontophoretic application (electrorepulsion: Nernst-Planck equation and/or electroosmosis).
  • Pharmacodynamic parameters (direct response, effect compartment or indirect response model).


 

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SKIN-CAD

SKIN-CAD is software for skin-body pharmacokinetic simulation developed based on percutaneous absorption model. SKIN-CAD can predict skin permeation amount and blood concentration by input of various model parameters. It can also analyze the effects of metabolism and binding in the skin, the enhancement by iontophoretic application, and the pharmacokinetic-pharmacodynamic model, etc.

SKIN-CAD can be used for optimizing the design of transdermal drug delivery systems (prediction of clinical performance, setup of administration schedule) as well as for evaluating the effects of various factors on skin permeation and blood concentration profiles. With the model parameters determined from in vitro or in vivo experiments or evaluated from correlation equations, SKIN-CAD can quickly provide you with graphical images; blood concentration - time profile for systemic application, drug distribution in the skin for topical application, skin permeability of skin-care products.
Pobierz testową wersję produktu Wróć do wszystkich produktów
  • Skin permeation model (2-layer or 1-layer).
  • Drug-dissolved matrix system/skin permeation model.
  • Drug-dispersed matrix system/skin permeation model.
  • Vehicle compartment/skin permeation model.

Serum fentanyl concentration-time profiles following transdermal delivery.


 
  • System application period, applied area.
  • Release characteristics from formulation.
  • Skin structure (thickness of each layer).
  • Diffusion and partition coefficients in skin.
  • Body pharmacokinetic parameters (1-, 2- or 3-compartment model).



Optional Input Parameters:
  • Skin binding parameters (Langmuir type or Freundlich type).
  • Skin metabolism parameters (Michaelis-Menten type or first-order kinetics).
  • Conditions of iontophoretic application (electrorepulsion: Nernst-Planck equation and/or electroosmosis).
  • Pharmacodynamic parameters (direct response, effect compartment or indirect response model).


 
SKIN-CAD can predict clinical performance using model parameters obtained from in vitro release or skin permeation studies. SKIN-CAD simulation will provide useful data to design transdermal and topical drug delivery systems. 



 
  • Cumulative amount permeated.
  • Blood concentration.
  • Drug distribution in matrix/skin.
  • Pharmacologic effect.




 

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